Articles, Patents, Reviews, Book Chapters

 

In preperation, coming soon:

 

Synthesis and in vitro evaluation of siderophore-drug conjugates based on a novel backbone modified enterobactin analog, R. Zscherp, J. Coetzee, J. Herrmann, P. Klahn*, 2019. (Fullpaper)

 

Novel natural compound with CRM1 and DUB activbity highlights a class of inhibitors with dual mode of action, V. Fetz, E. Thines, S. Knauer, P. Klahn, M. Brönstrup, O. Krämer, R. Stauber*, 2019. (Full Paper)

 

Published:

 

21) Labyrinthopeptins exert broad-spectrum antiviral activity through lipid-binding-mediated virolysis, H. Prochnow, K. Rox, N. V. S. Birudukota, L. Weichert, S.-K. Hotop, P. Klahn, K. Mohr, S.j Franz, D. Banda, S. Blockus, J. Schreiber, S. Haid, M. Oeyen, J. Martinez, R. Süssmuth, J. Wink, A. Meyerhans, C. Goffinet, M. Messerle, T. Schulz, A. Kröger, D. Schols, T. Pietschmann, M. Brönstrup, J. Virology  2019, accepted.  (Full Paper) 

 

20) The Nuclear Export Inhibitor Aminoratjadone is a Potent Effector in Extracellular-Targeted Drug Conjugates, P. Klahn*, V. Fetz, A. Ritter, W. Collisi, B. Hinkelmann, T. Arnold, W. Tegge, K. Rox, S. Hüttel, K. I. Mohr, J. Wink, M. Stadler, J. Wissings, L. Jänsch, M. Brönstrup*, Chem. Sci.  2019, 10, 5197-5210. (Full Paper)

 

19) Synthesis and biochemical evaluation of artificial, fluorescent glucosinolates (GSLs)C. P. Glindemann, A. Backenköhler, M. Strieker, U. Wittstock, P. Klahn*, ChemBioChem 2019, 19, 1668-1694. (Communication)

 

18) New targeted cytotoxic Ratjadone derivatives and conjugates thereof, P. Klahn, M. Brönstrup, V. Fetz, S. Hüttel, K. I. Mohr, W. Tegge, W. Collisi, 2019WO2019/03028431 A1 (Patent)  

 

17) Trimethyl Lock ‐ A Multifunctional Molecular Tool for Drug Delivery, Cellular Imaging and Stimuli‐responsive Materials, O. Adeyi Okoh, P. Klahn*, ChemBioChem  2018, 19, 1668-1694. (Review Article)

  

16) Leitfaden durch Experimente -  Theorie und Praxis gut verknüpft, C. Glindemann, P. Klahn*, Nachrichten der Chemie 2018, 5, 556.  Book Review: Multi-Step Organic Synthesis, N.  R. Moumné, Wiley-VCH Weinheim, 2017. (Book Review)

 

15)  Bifunctional antimicrobial conjugates and hybrid antimicrobials, P. Klahn, M. Brönstrup, Nat. Prod. Rep. 2017, 34, 832-885. (Review article)

 

14) New structural templates for clinically validated and novel targets in antimicrobial drug research and development, P. Klahn, M. Brönstrup, Curr. Top. Microbiol. Immunol. 2016, 365-417. (Review article/book chapter, additionally published in: How to Overcome the Antibiotic Crisis: Facts, Challenges, Technologies and Future Perspectives, Eds. M. Stadler, P. Dersch, Springer Verlag, 2016.)

 

13) Abscisic Acid: a phytohormone and mammalian cytokine as novel pharmacon with potential for future development into clinical applications, P. Sakthivel, N. Sharma, P. Klahn, M. Gereke, D. Bruder, Curr. Med. Chem. 2016, 23, 1549-1570. (Review article)

 

12) Synthesis and biological evaluation of natural and designed tubulysines, K. C. Nicolaou, J. Yin, D. Mandal, R. D. Erande, P. Klahn, J. Yin, M. Aujay, J. Sandoval, J. Gavrilyuk, D. Vourloumis, J. Am. Chem. Soc. 2016, 138, 1698-1708. (Fullpaper)

 

11) Deacetoxy tubulysine H and analogs thereof, K. C. Nicolaou, D. Mandal, P. Klahn, J. Yin, D. Vourloumis, 2016, WO2016/138288 A1 (Patent)

 

10) Gold(I)-catalyzed heterocyclization of beta-alkynyl hydroxamic acids: Synthesis of isooxazolidin-3-ones, A. P. Häring, P. Klahn, M. Jübermann, F. Mohr, S. F. Kirsch, Monatshefte Chemie 2015, 146, 199. (Communication)

 

9) The Synthesis of alpha-Azidoesters and geminal Triazides, P. Klahn, S. F. Kirsch, H. Erhardt, A. F. Kotthaus, Angew. Chem. Int Ed. 2014, 53, 7913-7917; Über die Synthese von alpha-Azidoestern und geminalen Triaziden, P. Klahn, S. F. Kirsch, H. Erhardt, A. F. Kotthaus, Angew. Chem. 2014, 126, 8047-8051. (Communication, most accessed article 06/2014, highlighted in SYNSTORIES 2014/11, A147.)

 

8) IBX-mediated dehydrogenation of substituted beta-oxonitrils, P. Klahn, S. F. Kirsch, Eur. J. Org. Chem. 2014, 15, 3149-3155. (Communication)

 

7) Total Synthesis of (+)-Cyperolone, P. Klahn, A. Duschek, C. Liebert, S. F. Kirsch, Org. Lett. 2012, 14, 1250-1253. (Communication, highlighted in Synfacts 2012, 8, 479 and Org. Lett. 2013, 15, 3181-3198.)

 

6) Practical Azidation of 1,3-Dicarbonyls, T. Harschneck, S. Hummel, S. F. Kirsch, P. Klahn, Chem. Eur. J. 2012, 18, 1178-1193. (Fullpaper, highlighted in Cheminform 2012, 43, 5.)

 

5) Book Review: Innovative Catalysis in Organic Synthesis, Ed. Pher. G. Anderson, Wiley-VCH, 2012, P. Klahn, S. F. Kirsch, Nachrichten der Chemie 2013, 7/8, 805. (Book Review)

 

4) Electronic Fine-Tuning of Carbene Ligands and its Impact on Gold Catalysis, P. Klahn, S. F. Kirsch, ChemCatChem 2011, 3, 649-652. (Highlight Article)

 

3) The Use of COP-OAc in the Catalyst-controlled Synthesis of 1,3-Polyols, S. F. Kirsch, P. Klahn, H. Menz, Synthesis 2011, 3592-3603. (Fullpaper)

 

2) Thienopyrimidines as beta-3-adrenoreceptor agonists: Hit to lead optimization, S Tasler, R. Baumgartner, A. Ammendola, J. Schachtner, T. Wieber, M. Blisse, S. Rath, M. Zaja, P. Klahn, U. Quotschalla, P. Ney, Bioorg. Med. Chem. Lett. 2010, 20, 6180-6115. (Communication)

 

1) Gold-catalyzed reactivity of 3-silyloxy-1,5-enynes: a synthetic tool for the synthesis of complex structures and its limitations, H. Menz, J. T. Binder, B. Crone, A. Duschek, T. T. Haug, S. F. Kirsch, P. Klahn, C. Liebert, Tetrahedron 2009, 65, 9, 1880-1888. (Fullpaper)